Chapter 1: Sirtuins
Meet Sirtuins: a family of seven master proteins (SIRT1 through SIRT7) that act as your cell's dedicated internal repair crew.
From repairing DNA damage caused by UV and environmental stressors to mitigating the inflammaging cascade and supporting metabolic health, sirtuins are a key focus in modern longevity science.
In our preclinical in vitro testing, OCEANBOOST™ FG demonstrated the ability to restore SIRT1 expression under acute stress to levels comparable to Resveratrol, the Longevity Industry's benchmark for performance.
But there is a major catch: sirtuins are co-dependent and cannot perform any of these tasks on their own.
If you've heard of sirtuins, then you've probably heard a lot about NAD+, and you guessed it, NAD+ is sirtuins' crutch; without it, they cannot operate.
Chapter 2: NAD+
Is boosting NAD+ actually missing half the picture?
NAD+ has taken the wellness world by storm, and for good reason. Beyond fueling cellular energy and genomic stability pathways, it is the vital fuel required to activate sirtuins, our cell's master repair proteins.
While flooding the body with precursors might seem like a logical way to boost NAD+ levels, there is a key part of this mechanism we need to consider.
Inside cells, NAD+ constantly flips between two states: active NAD+ (oxidized) and NADH (reduced). As your cells produce energy, NAD+ picks up electrons to become NADH, then drops them off in the mitochondria (your cell’s powerhouses) to generate ATP before recycling back. Sirtuins are co-dependent on NAD+ to function. Under oxidative stress, this recycling system breaks down; NADH accumulates and blocks sirtuins activity.
This balance is called the NAD+/NADH redox ratio. While precursors focus on adding more fuel to the tank, protecting this balance suggests a more biomimetic approach: supporting the cell's natural capacity to keep its existing fuel circulating and usable when stress hits.
In our preclinical in vitro testing, OCEANBOOST™ FG sustained this ratio under acute stress, successfully restoring the redox balance and SIRT1 expression back to healthy baseline levels.
To find out more, download the Fact Sheet below, or contact us to book an introduction to discuss how OCEANBOOST™ FG can become a cornerstone in your next functional food or supplement formulation.
Interested in learning more?
Our Product Development Activist Marc Desmarais will be joining the the fourth Cosmetics Business Roundtable event that will explore Healthy Ageing & Skin Science: The Innovations Driving Longevity.
Date: 10 September 2026
Time: 15:00 BST / 16:00 CEST / 10:00 EDT
Duration: 75 minutes approx.